Hydrochloric Acid → Phenyl[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methanone hydrochloride

Participants

Reaction Steps

120 mg of phenyl[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methanone are taken up in 2 mL of methanol and the solution is treated with 2 mL of a 4N solution of hydrogen chloride in dioxane and then with 2 mL of diethyl ether. The solution is stirred for 16 hours at room temperature and then concentrated under reduced pressure. The solid obtained is dried to give 85 mg of phenyl[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methanone hydrochloride (1:1) in the form of a beige-colored solid.

Provenance & Evidence