2-Amino-5-nitropyridine → HCID 67273481, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.48 g of 3-bromo-1-phenylpropane-1,2-dione in a mixture of 3 mL of THF and 0.5 mL of ethanol is added 0.25 g of 2-amino-5-nitropyridine. The reaction mixture is heated for 15 minutes at 160° C. in a microwave machine. The solid formed is separated out, taken up in 3 mL of ethanol and refluxed for 6 hours. After evaporating off the solvent, the residue is taken up in ethyl acetate and diluted with sodium hydroxide solution. The organic phase is washed with water, dried and then evaporated to give 0.42 g of (6-nitroimidazo[1,2-a]pyridin-2-yl)(phenyl)methanone in the form of a brown solid, which is used without further purification.

Provenance & Evidence