6-Aminonicotinic acid → HCID 67273587, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 0.33 g of 6-aminonicotinic acid in 5 mL of THF and 3 mL of ethanol is added a solution of 0.654 g of 3-bromo-1-phenylpropane-1,2-dione in 2 mL of THF. The reaction mixture is stirred at 45° C. for 16 hours and for 24 hours at 20° C., and then evaporated to dryness. The residue is taken up in dichloromethane and the solid is filtered off and washed with dichloromethane to give 0.78 g of 2-benzoylimidazo[1,2-a]pyridine-6-carboxylic acid hydrobromide in the form of a yellow solid.

Provenance & Evidence