反应详情

The N,N-dimethyl-6-nitropyridine-3-amine obtained above is taken up in 25 mL of ethanol. After addition of 4.8 g of stannous chloride, the reaction mixture is refluxed for 30 minutes and then concentrated to dryness. The residue is chromatographed on a column of silica, eluting with a 90/10 mixture of dichloromethane and ammoniacal methanol. The fractions containing the expected product are combined and concentrated to give 750 mg of 5-dimethylaminopyridine-2-amine in the form of a pasty yellow solid.

1. temperaturethe reaction mixture is refluxed for 30 minutes
2. concentrationconcentrated to dryness
3. customThe residue is chromatographed on a column of silica
4. washeluting with a 90/10 mixture of dichloromethane and ammoniacal methanol
5. additionThe fractions containing the expected product
6. concentrationconcentrated