4-Amino-1-butanol → HCID 86628445, compound

Temperature

75 °C

A mixture of 3-bromomethyl-pentane (3.0 g, 20 mmol) and 4-amino-1-butanol (5.06 mL, 55 mmol) in ethanol (20 mL) was heated at 75° C. for 16 h. The reaction mixture was concentrated and the resulting residue was diluted with dichloromethane (50 mL). The organic layer was partitioned with water (50 mL) and the aqueous layer extracted with dichloromethane (20 mL). Combined organic layers were dried over magnesium sulfate, filtered, and concentrated to give the title compound as an oil (2.8 g).

1. concentrationThe reaction mixture was concentrated
2. additionthe resulting residue was diluted with dichloromethane (50 mL)
3. customThe organic layer was partitioned with water (50 mL)
4. extractionthe aqueous layer extracted with dichloromethane (20 mL)
5. dry with materialCombined organic layers were dried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated

ORD record

ord-d2aa29eef1d24f2790b5f751fb317d73

Source dataset

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07902221B2