Water → 2-(Isoquinolin-7-yloxy)pentanoic acid sodium salt

HRID 600661Notes

Reaction equation

HRID 600661 reaction equation
O.[OH-].[Na+:3].[CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH:15]([CH2:21][CH2:22][CH3:23])[C:16]([O:18]CC)=[O:17])[CH:12]=2)[CH:7]=[CH:6][N:5]=1>CO>[Na+:3].[CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH:15]([CH2:21][CH2:22][CH3:23])[C:16]([O-:18])=[O:17])[CH:12]=2)[CH:7]=[CH:6][N:5]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 12044954Ethyl 2-(isoquinolin-7-yloxy)-pentanoate

Product 1

HCID 672684982-(Isoquinolin-7-yloxy)pentanoic acid sodium salt

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 ml of water and 840 mg (21.0 mmol) of sodium hydroxide are added to a solution of 5.20 g (19.0 mmol) of ethyl 2-(isoquinolin-7-yloxy) -pentanoate in 50 ml of methanol, and the mixture is stirred at room temperature for 42 hours. The solvent is removed by distillation, giving 2-(isoquinolin-7-yloxy)pentanoic acid sodium salt as a colourless solid; ESI 246.

Workup

  1. customThe solvent is removed by distillation

Sources & evidence

ORD record
ord-cbb8d4ba22014274923d23200a4f0d41
Source dataset
uspto-grants-2011_03
Patent number
US07902223B2

Reaction notes

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