HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → N-[4-(2-oxopiperidin-1-yl)phenyl]-2-(isoquinolin-7-yloxy)pentanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-(4-Aminophenyl)piperidin-2-one | HCID 11458178 | — |
| Reactant | 2-(Isoquinolin-7-yloxy)pentanoic acid sodium salt | HCID 67268498 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[4-(2-oxopiperidin-1-yl)phenyl]-2-(isoquinolin-7-yloxy)pentanamide | HCID 12044955 | — |
Reaction Steps
390 ml (3.55 mmol) of 4-methylmorpholine are added to a solution of 940 mg (3.52 mmol) of 2-(isoquinolin-7-yloxy)pentanoic acid sodium salt, 670 mg (3.52 mmol) of 1-(4-aminophenyl)piperidin-2-one, 670 mg (3.52 mmol) of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (DAPECI) and 480 mg (3.56 mmol) of 1-hydroxybenzotriazole (HOBt) in 2 ml of DMF, and the mixture is stirred at room temperature for 18 hours. The reaction mixture is introduced into water, and the precipitate is filtered off, giving N-[4-(2-oxopiperidin-1-yl)phenyl]-2-(isoquinolin-7-yloxy)pentanamide as a colourless solid; ESI 418.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902223B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-2e7c36645f224a22b63d6cd31e65209c |
| Source note | uspto-grants-2011_03 |