Water → 1-(4-Amino-2-methylphenyl)piperidin-2-one

HRID 600665Notes

Reaction equation

HRID 600665 reaction equation
O.[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]2=[O:17])=[C:7]([CH3:18])[CH:6]=1)([O-])=O>CO>[NH2:2][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]2=[O:17])=[C:7]([CH3:18])[CH:6]=1

Participants

4

Reactant 2

HCID 962WaterHCID 58806107HCID 58806107, compound

Product 1

HCID 115575081-(4-Amino-2-methylphenyl)piperidin-2-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

800 mg of water-moist palladium on activated carbon are added to a solution of 4.00 g (17.1 mmol) of 1-(4-nitro-2-methylphenyl)piperidin-2-one in 150 ml of methanol, and the mixture is hydrogenated at room temperature and atmospheric pressure for 22 hours. The reaction mixture is filtered, and the filtrate is evaporated, giving 1-(4-amino-2-methylphenyl)piperidin-2-one as a colourless solid; ESI 205.

Workup

  1. customis hydrogenated at room temperature
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-e039fad69f8548f79c6cc545947a2fc7
Source dataset
uspto-grants-2011_03
Patent number
US07902223B2

Reaction notes

Loading…