HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 600666Generated: October 29, 2026
Isoquinolin-7-amine → Methyl 2-(isoquinolin-7-ylamino)-4-methylpentanoate
https://huagongshe.com/reaction/600666
Participants
| Role | Name | HCID | Charge |
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| Reactant | Isoquinolin-7-amine | HCID 14660277 | — |
| Reactant | 2-Diazonio-1-methoxy-4-methylpent-1-en-1-olate | HCID 71330753 | — |
| Catalyst | Acetic acid, rhodium(2+) salt | HCID 21674 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 2-(isoquinolin-7-ylamino)-4-methylpentanoate | HCID 60126917 | — |
Reaction Steps
800 mg of rhodium(II) acetate (dimer) are added to a solution of 5.19 g (36.0 mmol) of 7-aminoisoquinoline and 5.47 g (35.0 mmol) of methyl 2-diazo-4-methylpentanoate in 200 ml of toluene, and the mixture is heated at 80° C. for 12 hours. The cooled reaction mixture is filtered, and the filtrate is evaporated. The residue is chromatographed on a silica-gel column with ethyl acetate as eluent, giving methyl 2-(isoquinolin-7-ylamino)-4-methylpentanoate as a yellowish solid; ESI 273.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07902223B2 |
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| Source dataset | uspto-grants-2011_03 |
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| ORD ID | ord-6c9496d5f5e94f30bd9246b0e0ff99f5 |
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| Source note | uspto-grants-2011_03 |
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