HCID 136343926, compound → HCID 136343927, compound

Participants

Reaction Steps

15 (0.09 mmol) was stirred in AcOH/THF/H2O (3/6/1) solution at 50° C. for 1 day. The reaction mixture was then concentrated under reduced pressure and purified by silica gel chromatography, C18 (H2O/ACN) Beige lyophilisated powder. Molecular Formula C12H12FN5O5. 1H NMR (DMSO-d6, 400 MHz) δ (ppm) 2.57-2.74 (m, 2H), 3.56 (s, 1H), 3.61-3.64 (d, J=12.10 Hz, 1H), 3.79-3.82 (d, J=12.10 Hz, 1H), 3.91-3.93 (d, J=5.40 Hz, 1H), 4.32-4.35 (m, 1H), 5.25 (s, 1H), 6.06-6.10 (d, J=18.20 Hz, 1H), 6.64 (s, 1H), 8.01 (s, 1H), 10.82 (s, 1H) 19F NMR (DMSO-d6, 376 MHz) δ (ppm) −138.4 (s, 1F). Scan ES− 292 (M+H)−, Scan ES+ 316 (M+Na)+, UV λmax 251 nm

Provenance & Evidence