HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-Hydroxy-6-methoxy-3-pyridinecarboximidoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 6-Methoxy-pyridine-3-carboxaldehyde oxime | HCID 76564449 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Hydroxy-6-methoxy-3-pyridinecarboximidoyl chloride | HCID 76564447 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To oxime 1c (1.25 g; 8.18 mmol) in concentrated hydrochloric acid (6.0 mL) at 0° C., was added dropwise bleach (9 mL). The reaction mixture was stirred at 0° C. for 1 h, diluted with water (20 mL) and brought to about pH=3 with saturated sodium bicarbonate. The resulting solid was collected, washed with water and dried. 2c was isolated as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902227B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-924c994f1adb459a87e50d9072904c94 |
| Source note | uspto-grants-2011_03 |