HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxy-N-hydroxybenzenecarboximidoyl chloride → cis-3-(4-Methoxyphenyl)-3a,4,6,6a-tetrahydro-pyrrolo[3,4-d]isoxazole-5-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxy-N-hydroxybenzenecarboximidoyl chloride | HCID 2763371 | — |
| Reactant | cis-3-(4-Chlorophenyl)-3a,4,6,6a-tetrahydro-pyrrolo[3,4-d]isoxazole-5-carboxylic acid tert-butyl ester | HCID 68971118 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | cis-3-(4-Methoxyphenyl)-3a,4,6,6a-tetrahydro-pyrrolo[3,4-d]isoxazole-5-carboxylic acid tert-butyl ester | HCID 68797285 | — |
Reaction Steps
The title compound was prepared in an analogous manner as the 4-chlorophenyl cycloadduct 3a using chloro oxime 2b. However, two additional portions of chloro oxime and triethyl amine were used. 3b was isolated as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902227B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-fd258371b26f405685d0cbb008e9daf2 |
| Source note | uspto-grants-2011_03 |