HuagongsheHuagongshe Chemistry Print Report · For research reference only
cis-3-(6-Methoxypyridin-3-yl) 3a,4,6,6a-tetrahydro-pyrrolo[3,4-d]isoxazole-5-carboxylic acid tert-butyl ester → cis-3-(6-Trifluoromethylpyridin-3-yl) 3a,4,6,6a-tetrahydro-pyrrolo[3,4-d]isoxazole-5-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | cis-3-(6-Methoxypyridin-3-yl) 3a,4,6,6a-tetrahydro-pyrrolo[3,4-d]isoxazole-5-carboxylic acid tert-butyl ester | HCID 68971835 | — |
| Reactant | N-Hydroxy-6-trifluoromethyl-3-pyridinecarboximidoyl chloride | HCID 76564437 | — |
| Product | cis-3-(6-Trifluoromethylpyridin-3-yl) 3a,4,6,6a-tetrahydro-pyrrolo[3,4-d]isoxazole-5-carboxylic acid tert-butyl ester | HCID 68974391 | — |
Reaction Steps
The title compound was prepared in an analogous manner as the 4-methoxy-3-pyridyl cycloadduct 3c using chloro oxime 2d. 3d was isolated as a white solid after chromatography with 25% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902227B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-747787daef3740548e7e9bd3b17eeae3 |
| Source note | uspto-grants-2011_03 |