Triethylamine → HCID 25206945, compound

Participants

Reaction Steps

7-Chloro-1-(2,4-difluorophenyl-6-fluoro-4-oxo-1,4-dihydronapthyridine-3-carboxylic acid (50) (120 mg; 0.34 mmol), trifluoroacetate salt 4a (131 mg; 0.39 mmol) and triethylamine (0.3 mL) in acetonitrile (3 mL) were heated at reflux temperature overnight. After cooling, the volatiles were evaporated. The residue was triturated with water, filtered and dried to yield acid 101 as an off-white solid.

Provenance & Evidence