HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyrroline → 1-Cyclopropyl-7-(2,5-dihydro-pyrrol-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyrroline | HCID 66059 | — |
| Reactant | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid | HCID 7019465 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Cyclopropyl-7-(2,5-dihydro-pyrrol-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid | HCID 57555552 | — |
Reaction Steps
3-Pyrroline (1 g; 14.5 mmol) and acid 52 (2.1 g; 7.2 mmol) in DMF (10 mL) were heated at 100° C. overnight. After cooling, the reaction mixture was filtered and washed with water. Acid 119 was isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902227B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-1da1e17941e34c4a9e432bb6fbb527e6 |
| Source note | uspto-grants-2011_03 |