N-(7-ethoxy-5,8-dihydronaphthalen-1-yl)-5-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-amine → 8-{[5-(4-pyrrolidin-1-ylphenyl)-1,3-oxazol-2-yl]amino}-3,4-dihydronaphthalen-2(1H)-one

HRID 600780Notes

Reaction equation

HRID 600780 reaction equation
ClC1C=CC(C2OC(NC3C4CC(OCC)=CCC=4C=CC=3)=NC=2)=CC=1.C([O:29][C:30]1[CH2:39][C:38]2[C:37]([NH:40][C:41]3[O:42][C:43]([C:46]4[CH:51]=[CH:50][C:49]([N:52]5[CH2:56][CH2:55][CH2:54][CH2:53]5)=[CH:48][CH:47]=4)=[CH:44][N:45]=3)=[CH:36][CH:35]=[CH:34][C:33]=2[CH2:32][CH:31]=1)C.C(OC1CC2C(NC3OC(C4C=CC(C(F)(F)F)=CC=4)=CN=3)=CC=CC=2CC=1)C>>[N:52]1([C:49]2[CH:48]=[CH:47][C:46]([C:43]3[O:42][C:41]([NH:40][C:37]4[CH:36]=[CH:35][CH:34]=[C:33]5[C:38]=4[CH2:39][C:30](=[O:29])[CH2:31][CH2:32]5)=[N:45][CH:44]=3)=[CH:51][CH:50]=2)[CH2:56][CH2:55][CH2:54][CH2:53]1

Participants

3

Reactant 2

HCID 67229299N-(7-ethoxy-5,8-dihydronaphthalen-1-yl)-5-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-amineHCID 67229691N-(7-ethoxy-5,8-dihydronaphthalen-1-yl)-5-(4-pyrrolidin-1-ylphenyl)-1,3-oxazol-2-amine 5-(4-chlorophenyl)-N-(7-ethoxy-5,8-dihydronaphthalen-1-yl)-1,3-oxazol-2-amine

Product 1

HCID 672295858-{[5-(4-pyrrolidin-1-ylphenyl)-1,3-oxazol-2-yl]amino}-3,4-dihydronaphthalen-2(1H)-one

Procedure

The title compound was prepared using the procedure as described in Example 1I, substituting the product of Example 7B for the product of Example 1H.

Sources & evidence

ORD record
ord-0e1bcfe656a3417cb402d94f3d10b9a6
Source dataset
uspto-grants-2011_03
Patent number
US07902236B2

Reaction notes

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