8-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-one → 8-[5-(4-Methoxyphenyl)oxazol-2-ylamino]-1,2,3,4-tetrahydronaphthalen-2-ol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	8-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-one	HCID 11955840	—
Edukt	8-{[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]amino}-3,4-dihydronaphthalen-2(1H)-one	HCID 11964236	—
Produkt	8-[5-(4-Methoxyphenyl)oxazol-2-ylamino]-1,2,3,4-tetrahydronaphthalen-2-ol	HCID 11964282	—

Reaktionsschritte

The title compound was prepared using the procedure as described in Example 2, substituting the product of Example 10C for the product of Example 1I. 1H NMR (DMSO-d6) δ 8.98 (s, 1H), 7.59 (d, 1H, J=7.8 Hz), 7.49 (d, 2H, J=8.8 Hz), 7.20 (s, 1H), 7.08 (t, 1H, J=7.6 Hz), 7.00 (d, 2H, J=8.8 Hz), 6.82 (d, 1H, J=7.4 Hz), 4.79 (d, 1H, J=4.1 Hz), 3.93 (m, 1H), 3.78 (s, 3H), 2.74-2.98 (m, 4H), 1.85 (m, 1H), 1.63 (m, 1H); MS (ESI+) m/z 337 (M+H).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07902236B2
Quelldatensatz	uspto-grants-2011_03
ORD ID	ord-c71fdcc819b9476baef87e6e144c10ec
Quellennotiz	uspto-grants-2011_03