Cyanogen Bromide → HCID 57667099, compound

HRID 600837Notes

Reaction equation

Cl.Cl.[NH2:3][C@@H:4]([CH2:7][N:8]([CH:15]([CH3:17])[CH3:16])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:5][OH:6].[N:18]#[C:19]Br>>[CH:15]([N:8]([CH2:7][C@H:4]1[CH2:5][O:6][C:19]([NH2:18])=[N:3]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([CH3:17])[CH3:16]

Participants

Reactant 2

HCID 10476Cyanogen Bromide

HCID 67271343HCID 67271343, compound

Product 1

HCID 57667099HCID 57667099, compound

Procedure

In analogy to example 1.d (S)-2-amino-3-(isopropyl-phenyl-amino)-propan-1-ol dihydrochloride was reacted with cyanogen bromide to give (S)-4-[(isopropyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine as light yellow amorphous solid. MS (ISP): 234.3 ([M+H]+)

Sources & evidence

ORD record: ord-7a94291286934a15bdffa1f25e37e218
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902238B2

Reaction notes

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