Cyanogen Bromide → HCID 67270529, compound

HRID 600840Notes

Reaction equation

[NH2:1][C@@H:2]([CH2:5][N:6]([C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)[CH:7]([CH3:9])C)[CH2:3][OH:4].[N:23]#[C:24]Br>>[CH2:16]([C:13]1[CH:14]=[CH:15][C:10]([N:6]([CH2:5][CH:2]2[CH2:3][O:4][C:24]([NH2:23])=[N:1]2)[CH2:7][CH3:9])=[CH:11][CH:12]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Reactant 2

HCID 10476Cyanogen Bromide

HCID 57667120HCID 57667120, compound

Product 1

HCID 67270529HCID 67270529, compound

Procedure

In analogy to example 1.d (S)-2-amino-3-[(4-benzyl-phenyl)-isopropyl-amino]-propan-1-ol was reacted with cyanogen bromide to give S)-4-{[(4-benzyl-phenyl)-ethyl-amino]-methyl}-4,5-dihydro-oxazol-2-ylamine. Colorless gum. MS (ISP): 310.4 ([M+H]+)

Sources & evidence

ORD record: ord-607832a92c7e4de1aacdcd2259d505b7
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902238B2

Reaction notes

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