Cyanogen Bromide → HCID 57667091, compound

HRID 600841Notes

Reaction equation

[NH2:1][C@@H:2]([CH2:5][N:6]([C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)[CH:7]([CH3:9])[CH3:8])[CH2:3][OH:4].[N:23]#[C:24]Br>>[CH2:16]([C:13]1[CH:12]=[CH:11][C:10]([N:6]([CH2:5][C@H:2]2[CH2:3][O:4][C:24]([NH2:23])=[N:1]2)[CH:7]([CH3:8])[CH3:9])=[CH:15][CH:14]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Reactant 2

HCID 10476Cyanogen Bromide

HCID 57667120HCID 57667120, compound

Product 1

HCID 57667091HCID 57667091, compound

Procedure

In analogy to example 1.d (S)-2-amino-3-[(4-benzyl-phenyl)-isopropyl-amino]-propan-1-ol was reacted with cyanogen bromide to give (S)-4-{[(4-benzyl-phenyl)-isopropyl-amino]-methyl}-4,5-dihydro-oxazol-2-ylamine. Light yellow gum. MS (ISP): 324.4 ([M+H]+)

Sources & evidence

ORD record: ord-3517ed1fea064212a4d4b1de5b0d3ca2
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902238B2

Reaction notes

Loading…