Cyanogen Bromide → HCID 57667047, compound

HRID 600851Notes

Reaction equation

[NH2:1][C:2]([CH3:15])([CH2:5][N:6]([CH2:13][CH3:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][OH:4].[N:16]#[C:17]Br>>[CH2:13]([N:6]([CH2:5][C:2]1([CH3:15])[CH2:3][O:4][C:17]([NH2:16])=[N:1]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:14]

Participants

Reactant 2

HCID 10476Cyanogen Bromide

HCID 57666998HCID 57666998, compound

Product 1

HCID 57667047HCID 57667047, compound

Procedure

In analogy to example 1.d (RS)-2-amino-3-(ethyl-phenyl-amino)-2-methyl-propan-1-ol was reacted with cyanogen bromide to give (RS)-4-[(ethyl-phenyl-amino)-methyl]-4-methyl-4,5-dihydro-oxazol-2-ylamine as a colourless gum. MS (ISP): 234.0 ([M+H]+).

Sources & evidence

ORD record: ord-93ee4ff038a342a5a0b41dba4c248896
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902238B2

Reaction notes

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