反应详情

温度

40 °C

3-(R)-[1-[N-(tert-butoxycarbonyl)-N-(methyl)amino]cyclopropyl]-1-[1-(S)-phenylethyl]pyrrolidine (7.19 g, 20.9 mmol) was dissolved in ethanol (78 ml), and after adding a 10% palladium carbon catalyst (water content: 50%; 3.9 g), it was stirred at 40° C. for 4 hours under a hydrogen atmosphere at atmospheric pressure. After performing filtration through cellite (ethanol washing), the filtrate was concentrated under a reduced pressure. As a result, 4.38 g (quantitative) of the title compound was obtained in the form of a colorless syrup. The 1H-NMR data and the TLC Rf value of this resulting compound agreed with the data indicated previously.

1. filtrationfiltration through cellite (ethanol washing)
2. concentrationthe filtrate was concentrated under a reduced pressure