3-(R)-[1-[N-(tert-butoxycarbonyl)-N-(ethyl)Amino]Cyclopropyl]-1-[1-(S)-phenylethyl]Pyrrolidine → 3-(R)-[1-[N-(tert-butoxycarbonyl)-N-(ethyl)amino]cyclopropyl]pyrrolidine

Participants

Reaction Conditions

Reaction Steps

3-(R)-[1-[N-(tert-butoxycarbonyl)-N-(ethyl)amino]cyclopropyl]-1-[1-(S)-phenylethyl]pyrrolidine (3.01 g, 8.40 mmol) was dissolved in ethanol (120 ml), and after adding a 10% palladium carbon catalyst (water content: 50%; 3.0 g), it was stirred at 40° C. for 5 hours under a hydrogen atmosphere at atmospheric pressure. After performing filtration through cellite (ethanol washing), the filtrate was concentrated under a reduced pressure. As a result, 2.16 g (quantitative) of the title compound was obtained in the form of a colorless syrup.

Provenance & Evidence