Sodium Phosphate, Dibasic → HCID 9863575, compound

Participants

Reaction Steps

To a solution of 3-(16-hydroxyhexadecyl)-1-(4-methoxybenzenesulfonyl)indole (400 mg, 0.72 mmol) dissolved in 20 ml of dry methanol were added disodium hydrogenphosphate (205 mg, 1.44 mmol) and amalgam chloride (6%, 4 g) at 0° C. under argon gas. After the resulting mixture was allowed to stand at room temperature for 12 hours, 50 mL of ammonium chloride was added thereto. The resulting mixture was extracted three times with 60 ml of ethyl ether. The combined organic layer was washed with saline, dried over anhydrous magnesium sulfate and then concentrated. The residue was purified by chromatography on a silica gel column to give 3-(16-hydroxyhexadecyl)indole (Compound 1) as a white solid (204 mg, 75%).

Provenance & Evidence