Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydrazine, (2-fluorophenyl)-, hydrochloride (1:1) | HCID 2723910 | — |
| Reactant | HCID 58976687 | HCID 58976687 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 9949363 | HCID 9949363 | 89.3% |
Reaction Steps
A mixture of N-cyano-N′-(2,4-dimethoxyphenyl)-O-phenylisourea (0.10 g, 0.34 mmol), 2-fluoro-phenylhydrazine hydrochloride (0.08 g, 0.50 mmol) and triethylamine (0.01 mL, 0.68 mmol) in isopropanol (3 mL) was heated at 100° C. for 18 h and evaporated. Purification by flash chromatography (SiO2) eluted with 1:1 ethyl acetate:hexanes provided the title compound (0.10 g, 85% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07902239B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-bb3429d0af524f41ac633aea370d5311 |
|---|
| Source note | uspto-grants-2011_03 |
|---|
