Triethylamine → HCID 56595552, compound

Participants

Reaction Steps

To N-cyano-N′-(3,4-dimethoxy-phenyl)-O-phenylisourea (0.215 g, 0.723 mmoles) in isopropanol (3 mL) was added 0.184 g (1.5 equivalents) of 4-Hydrazino-benzonitrile hydrochloride, followed by triethylamine 152 uL (1.5 equivalents) and catalytic (0.2 equivalents) 4-dimethylaminopyridine. The reaction was stirred overnight at 100 degrees Celsius. The reaction mixture was concentrated to dryness and purified by reverse phase column chromatography. The pure fractions were dried to provide 4-[5-amino-3-(3,4-dimethoxy-phenylamino)-[1,2,4]triazol-1-yl]-benzonitrile as tan solid (18.3 mg, 7.5% yield).

Provenance & Evidence