Diethyl Ether → HCID 58976508, compound

Participants

Reaction Steps

To a solution of (50 mg; 0.12 mMol) of 1-(2-methanesulfonyl-6-phenylamino-pyrimidin-4-yl)-N3-phenyl-1H-[1,2,4]triazole-3,5-diamine in 2 mL of DMSO was added 8 mg (0.13 mMol) of potassium cyanide and reaction was stirred for 1 hr at ambient temperature. The solvent was removed under reduced pressure. The residue was triturated with water and the solid was isolated via suction filtration. Column chromatography (SiO2, 5% EtOH—CH2Cl2) followed by trituration with diethyl ether affording 5 mg of an off white powder, (11% yield).

Provenance & Evidence