Phosphorus oxychloride → HCID 58976941, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-(3,4-Dimethoxy-phenylamino)-4H-[1,2,4]triazolo[1,5-a]quinazolin-5-one (57 mg) in phosphorus oxychloride (5 mL) was heated at 90° C. for 2 h. Evaporation. The residue was suspended in dichloromethane, washed with cold sodium bicarbonate, brine and dried (Na2SO4). Filtration and concentration gave crude (5-Chloro-[1,2,4]triazolo[1,5-a]quinazolin-2-yl)-(3,4-dimethoxy-phenyl)-amine (68 mg). LC-MS: m/e=356.1 (M+H),

Provenance & Evidence