Methanol → Methyl 5-phenylpentanoate

HRID 601087Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:14]O>>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 887Methanol

HCID 16757Benzenepentanoic acid

Product 1

HCID 262942Methyl 5-phenylpentanoate

Procedure

5-Phenylpentanoic acid (10.0 g) was dissolved in 250 mL of methanol and sparged with hydrogen chloride gas at room temperature for 15 minutes. The solvent was then removed under vacuum. Methyl 5-phenylpentanoate obtained was used in the next step without further purification.

Workup

customsparged with hydrogen chloride gas at room temperature for 15 minutes
customThe solvent was then removed under vacuum

Sources & evidence

ORD record: ord-0a54314509774b6d87c74f678b21d28a
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902259B2

Reaction notes

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