ethyl 2-{[(2S)-2-methylbutyl]amino}nicotinate → 1-[(2S)-2-methylbutyl]-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione

HRID 601106Notes

Reaction equation

HRID 601106 reaction equation
[CH3:1][C@@H:2]([CH2:16][CH3:17])[CH2:3][NH:4][C:5]1[N:15]=[CH:14][CH:13]=[CH:12][C:6]=1[C:7]([O:9][CH2:10]C)=[O:8].C(C(CC)CNC1N=CC=CC=1C(OCC)=[O:26])C>>[CH3:1][C@@H:2]([CH2:16][CH3:17])[CH2:3][N:4]1[C:5]2[N:15]=[CH:14][CH:13]=[CH:12][C:6]=2[C:7](=[O:8])[O:9][C:10]1=[O:26]

Participants

3

Reactant 2

HCID 67063398ethyl 2-{[(2S)-2-methylbutyl]amino}nicotinateHCID 67064133Ethyl 2-[(2-ethylbutyl)amino]nicotinate

Product 1

HCID 865921031-[(2S)-2-methylbutyl]-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione

Procedure

The title compound was prepared according to the procedure of Example 3B substituting the product of Example 20A for the product of Example 3A (0.400 g, 68%). MS (DCI) m/z 252 (M+NH4)+.

Sources & evidence

ORD record
ord-5fca16c5ac24461bae386984fce4dc12
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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