Benzylamine → HCID 86592109, compound

HRID 601115Notes

Reaction equation

HRID 601115 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:11][C:12](=[O:20])[C:13]1[CH:18]=[CH:17][CH:16]=[N:15][C:14]=1Cl)C.[CH2:21](C(CC)CN)C>>[CH2:1]([NH:8][C:14]1[N:15]=[C:16]([CH3:21])[CH:17]=[CH:18][C:13]=1[C:12]([O-:11])=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:2]1([CH2:1][NH3+:8])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 7504Benzylamine2×HCID 120492-Ethyl butylamineHCID 2796614Ethyl chloronicotinate

Product 1

HCID 86592109HCID 86592109, compound

Procedure

The title compound was prepared as a benzylamine salt according to the procedure of Example 3A substituting 2-chloro-6-methyl-nicotinic acid for 2-chloro-nicotinic acid ethyl ester and benzyl amine for 2-ethylbutylamine (0.480 g, 46%). MS (ESI+) m/z 243.03 (M+H)+; 1H NMR (300 MHz, CDCl3) δ 2.35 (s, 3H), 3.67 (s, 2H), 4.65 (s, 2H), 5.73 (br s, 3H), 6.16 (d, J=7.72 Hz, 1H), 7.17 (m, 10H), 7.76 (d, J=7.35 Hz, 1H), 8.66 (br s, 1H).

Sources & evidence

ORD record
ord-dcc6c1f229934a2f980113253baf0645
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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