HCID 28540643, compound → HCID 86592112, compound

HRID 601118Notes

Reaction equation

HRID 601118 reaction equation
[CH:1]1([NH:6][C:7]2[N:17]=[CH:16][CH:15]=[CH:14][C:8]=2[C:9]([O:11][CH2:12]C)=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(C(CC)CNC1N=CC=CC=1C(OCC)=[O:26])C>>[CH:1]1([N:6]2[C:7]3[N:17]=[CH:16][CH:15]=[CH:14][C:8]=3[C:9](=[O:10])[O:11][C:12]2=[O:26])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 28540643HCID 28540643, compoundHCID 67064133Ethyl 2-[(2-ethylbutyl)amino]nicotinate

Product 1

HCID 86592112HCID 86592112, compound

Procedure

The title compound was prepared according to the procedure of Example 3B substituting the product of Example 68A for the product of Example 3A (0.130 g, 56%). MS (ESI+) m/z 221.08 (M+H)+; 1H NMR (300 MHz, CDCl3) δ 1.66 (m, 1H), 1.99 (m, 4H), 2.21 (m, 2H), 5.79 (m, 1H), 7.25 (dd, J=8.09, 4.78 Hz, 1H), 8.42 (dd, J=7.72, 2.21 Hz, 1H), 8.70 (dd, J=4.78, 1.84 Hz, 1H).

Sources & evidence

ORD record
ord-d52162eaf4994d7eab9a84f55e6122b1
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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