HCID 28530831, compound → HCID 86592115, compound

HRID 601122Notes

Reaction equation

HRID 601122 reaction equation
[CH:1]1([NH:7][C:8]2[N:18]=[CH:17][CH:16]=[CH:15][C:9]=2[C:10]([O:12][CH2:13]C)=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(C(CC)CNC1N=CC=CC=1C(OCC)=[O:27])C>>[CH:1]1([N:7]2[C:8]3[N:18]=[CH:17][CH:16]=[CH:15][C:9]=3[C:10](=[O:11])[O:12][C:13]2=[O:27])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 28530831HCID 28530831, compoundHCID 67064133Ethyl 2-[(2-ethylbutyl)amino]nicotinate

Product 1

HCID 86592115HCID 86592115, compound

Procedure

The title compound was prepared according to the procedure of Example 3B substituting the product of Example 81A for the product of Example 3A (0.171 g, 35%). 1H NMR (300 MHz, CDCl3) δ 1.37 (m, 4H), 1.73 (m, 2H), 1.91 (m, 2H), 2.47 (ddd, J=24.82, 12.32, 3.31 Hz, 2H), 5.28 (tt, J=12.27, 3.72 Hz, 1H), 7.24 (dd, J=6.99, 4.04 Hz, 1H), 8.41 (dd, J=7.72, 2.21 Hz, 1H), 8.70 (dd, J=4.78, 2.21 Hz, 1H).

Sources & evidence

ORD record
ord-c452e44ce3eb4feaa15dfa680a439c8b
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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