Sodium Methoxide → HCID 67063385, compound

HRID 601149Notes

Reaction equation

[CH2:1]([N:8]([C:25](=[O:32])[CH2:26][C:27]([O:29][CH2:30]C)=[O:28])[C:9]1[N:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:12]=[CH:11][C:10]=1[C:20]([O:22]CC)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[Na+]>>[CH2:1]([N:8]1[C:25](=[O:32])[C:26]([C:27]([O:29][CH3:30])=[O:28])=[C:20]([OH:22])[C:10]2[CH:11]=[N:12][N:13]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:9]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 10942334Sodium Methoxide

HCID 67063577HCID 67063577, compound

Product 1

HCID 67063385HCID 67063385, compound

Procedure

The title compound was prepared from the product of Example 138B and sodium methoxide according to the procedure of Rowley, and co-workers as described in J. Med. Chem., 1993, 36, 3386-3396. MS (ESI−) m/z 374 (M−H)−.

Sources & evidence

ORD record: ord-f2e1d4b966194de2bd9ce3e4b18a3e7c
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902203B2

Reaction notes

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