HCID 67063445, compound → HCID 86594007, compound

HRID 601154Notes

Reaction equation

HRID 601154 reaction equation
[C:1]1([CH:7]([CH3:21])[CH2:8][NH:9][C:10]2[N:20]=[CH:19][CH:18]=[CH:17][C:11]=2[C:12]([O:14][CH2:15]C)=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(C(CC)CNC1N=CC=CC=1C(OCC)=[O:30])C>>[C:1]1([CH:7]([CH3:21])[CH2:8][N:9]2[C:10]3[N:20]=[CH:19][CH:18]=[CH:17][C:11]=3[C:12](=[O:13])[O:14][C:15]2=[O:30])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 67063445HCID 67063445, compoundHCID 67064133Ethyl 2-[(2-ethylbutyl)amino]nicotinate

Product 1

HCID 86594007HCID 86594007, compound

Procedure

The title compound was prepared according to the procedure of Example 3B substituting the product of Example 149A for the product of Example 3A (0.44 g, 99%). MS (DCI+) m/z 283 (M+H)−; 1H NMR (300 MHz, DMSO-d6) δ 1.26 (d, J=6.99 Hz, 3H), 3.37 (m, 1H), 4.21 (dd, J=13.24, 6.25 Hz, 1H), 4.36 (m, 1H), 7.21 (m, 1H), 7.29 (m, 4H), 7.38 (dd, J=7.72, 4.78 Hz, 1H), 8.39 (dd, J=7.72, 1.84 Hz, 1H), 8.77 (dd, J=4.78, 1.84 Hz, 1H).

Sources & evidence

ORD record
ord-5f18354c5adf46ab8acdf1c424a70750
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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