ethyl 4-(benzylamino)-2-(methylthio)pyrimidine-5-carboxylate → 4-(Benzylamino)-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

HRID 601155Notes

Reaction equation

HRID 601155 reaction equation
[CH2:1]([NH:8][C:9]1[C:14]([C:15]([O:17]CC)=[O:16])=[CH:13][N:12]=[C:11]([S:20][CH3:21])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(C(CC)CNC1C(C(OC)=O)=CN=C(SC)N=1)C>>[CH2:1]([NH:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[CH:13][N:12]=[C:11]([S:20][CH3:21])[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 295705ethyl 4-(benzylamino)-2-(methylthio)pyrimidine-5-carboxylateHCID 67063346HCID 67063346, compound

Product 1

HCID 289058134-(Benzylamino)-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

Procedure

The title compound was prepared according to the procedure of Example 108B substituting the product of Example 150A for the product of Example 108A. (0.185 g, 78%).

Sources & evidence

ORD record
ord-60911e9f796c48c4b4b2be0bb66a7165
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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