3-Azaisatoic anhydride → 1-butyl-2H-pyrido[3,2-d][1,3]oxazine-2,4(1H)-dione

HRID 601161Notes

Reaction equation

HRID 601161 reaction equation
[NH:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[N:10][C:5]=2[C:4](=[O:11])[O:3][C:2]1=[O:12].N1C2N=C[CH:21]=[CH:22][C:17]=2[C:16](=O)OC1=O>>[CH2:16]([N:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[N:10][C:5]=2[C:4](=[O:11])[O:3][C:2]1=[O:12])[CH2:17][CH2:22][CH3:21]

Participants

3

Reactant 2

HCID 109865823-Azaisatoic anhydrideHCID 131986941H-Pyrido[3,2-d][1,3]oxazine-2,4-dione

Product 1

HCID 865921231-butyl-2H-pyrido[3,2-d][1,3]oxazine-2,4(1H)-dione

Procedure

The title compound was prepared according to the procedure of Example 1B substituting the product of Example 159A for the product of Example 1A (0.12 g, 35%). 1H NMR (300 MHz, DMSO-d6) δ 0.92 (t, J=7.35 Hz, 3 H) 1.40 (m, J=15.26, 7.17 Hz, 2 H) 1.60 (m, 2 H) 3.98 (m, 2 H) 7.81 (dd, J=8.82, 4.41 Hz, 1 H) 7.97 (dd, J=8.64, 1.29 Hz, 1 H) 8.55 (dd, J=4.23, 1.29 Hz, 1 H).

Sources & evidence

ORD record
ord-c7e0aa3b106f4e82a541140fd76a8e28
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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