HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 601217Generated: October 30, 2026
Isobutyraldehyde → HCID 136374159, compound
https://huagongshe.com/reaction/601217
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isobutyraldehyde | HCID 6561 | — |
| Reactant | 4-amino-6-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-7-hydroxythieno[3,2-b]pyridin-5(4H)-one | HCID 136373627 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 136374159 | HCID 136374159 | 65% |
Reaction Steps
The product of Example 268D (0.10 g, 0.27 mmol) was reacted with 2-methyl-propionaldehyde (0.20 g, 2.77 mmol) in N,N-dimethylacetamide (3 mL) in a sealed tube at 135° C. for 40 minutes in a microwave reactor. The reaction was cooled to 25° C. and concentrated under vacuum. The resulting residue was triturated with a mixture of 25% ethyl acetate in hexanes and filtered to give the title compound as a solid (0.073 g, 65%). MS (APCI+) m/z 417 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07902203B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-86834cd6a7e149619afe1339e89261ec |
|---|
| Source note | uspto-grants-2011_03 |
|---|
