Sodium Hydroxide → HCID 117761285, compound

HRID 60122Notes

Reaction equation

HRID 60122 reaction equation
[OH-].[Na+:2].[CH3:3][C:4]1[N:5]=[C:6]([C:10]2[CH:11]=[N:12][N:13]([CH3:19])[C:14]=2[C:15]([O:17]C)=[O:16])[S:7][C:8]=1[CH3:9]>CO>[CH3:3][C:4]1[N:5]=[C:6]([C:10]2[CH:11]=[N:12][N:13]([CH3:19])[C:14]=2[C:15]([O-:17])=[O:16])[S:7][C:8]=1[CH3:9].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 90383255HCID 90383255, compound

Product 1

HCID 117761285HCID 117761285, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An aqueous solution (1 ml) of sodium hydroxide (9.6 mg) was added to a methanol (1 ml) solution of the methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate (30 mg) obtained in (Example 2.2) <Step 1>, and the obtained mixture was then heated to reflux for 15 minutes. Thereafter, the solvent was distilled away under reduced pressure, and the residue was then subjected to azeotropy with toluene, so as to obtain a crude product of the title compound.

Workup

  1. customobtained in (Example 2.2) <Step 1>
  2. temperaturethe obtained mixture was then heated
  3. temperatureto reflux for 15 minutes
  4. distillationThereafter, the solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-15b86845a3fb4a78b93f39e369f110a0
Source dataset
uspto-grants-2016_09
Patent number
US09440970B2

Reaction notes

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