Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Pentanone | HCID 7895 | — |
| Reactant | 4-amino-6-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-7-hydroxythieno[3,2-b]pyridin-5(4H)-one | HCID 136373627 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 136374196 | HCID 136374196 | — |
Reaction Steps
The product of Example 268D (0.073 g, 0.2 mmol) was reacted with pentan-2-one (0.9 g, 10.4 mmol) in N,N-dimethylacetamide (2 mL) in a sealed tube at 135° C. for 60 minutes in a microwave reactor. The reaction was cooled to 25° C. and concentrated under vacuum. The resulting residue was triturated with diethyl ether (3 mL) and filtered to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07902203B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-27e1d3e2f41e4b968eab258dea2c6fc4 |
|---|
| Source note | uspto-grants-2011_03 |
|---|
