HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 601274Generated: October 29, 2026
Cyclopropanecarboxaldehyde → HCID 136358483, compound
https://huagongshe.com/reaction/601274
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopropanecarboxaldehyde | HCID 123114 | — |
| Reactant | 4-amino-6-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-7-hydroxythieno[3,2-b]pyridin-5(4H)-one | HCID 136373627 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 136358483 | HCID 136358483 | 61.2% |
Reaction Steps
The product of Example 268D (0.15 g, 0.41 mmol) was reacted with cyclopropanecarbaldehyde (1.0 g, 14 mmol) in N,N-dimethylacetamide (3 mL) in a sealed tube at 120° C. for 90 minutes in a microwave reactor. The reaction was cooled to 25° C. and concentrated under vacuum. The resulting residue was triturated with diethyl ether and filtered to give the title compound (0.104 g, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07902203B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-893dfe9547f24fe788c4a3e39dd53ee5 |
|---|
| Source note | uspto-grants-2011_03 |
|---|
