Methanol → sodium 1-methyl-4-(4-(trifluoromethyl)thiazol-2-yl)-1H-pyrazole-5-carboxylate
Reaction equation
[OH-].[Na+:2].O.CO.[CH3:6][N:7]1[C:11]([C:12]([O:14]C)=[O:13])=[C:10]([C:16]2[S:17][CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[N:20]=2)[CH:9]=[N:8]1>C1(C)C=CC=CC=1>[CH3:6][N:7]1[C:11]([C:12]([O-:14])=[O:13])=[C:10]([C:16]2[S:17][CH:18]=[C:19]([C:21]([F:23])([F:22])[F:24])[N:20]=2)[CH:9]=[N:8]1.[Na+:2]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
Sodium hydroxide (3.5 mg) was added to a mixed solution of water (1 ml) and methanol (1 ml) containing the methyl 1-methyl-4-(4-(trifluoromethyl)thiazol-2-yl)-1H-pyrazole-5-carboxylate (13 mg) obtained in (Example 1.5) <Step 1>, and the obtained mixture was then stirred at 70° C. for 30 minutes. Thereafter, the reaction solution was subjected to azeotropy with toluene, so as to obtain the title compound (20 mg) in the form of a colorless solid.
Workup
- customobtained in (Example 1.5) <Step 1>
Sources & evidence
- ORD record
- ord-b1814132abfb4bab96aa54c7f41f5b18
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09440970B2
Reaction notes
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