1,4-Dioxane hydrochloride → 1622993-13-8

HRID 60133Notes

Reaction equation

HRID 60133 reaction equation
[ClH:1].O1CCOCC1.[Br:8][C:9]1[N:25]=[C:12]2[CH:13]=[C:14]([NH:17]C(=O)OC(C)(C)C)[CH:15]=[CH:16][N:11]2[N:10]=1>O1CCOCC1>[ClH:1].[Br:8][C:9]1[N:25]=[C:12]2[CH:13]=[C:14]([NH2:17])[CH:15]=[CH:16][N:11]2[N:10]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67774787HCID 67774787, compound

Product 1

HCID 1177612951622993-13-8

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A suspension of 4 N hydrochloric acid-1,4-dioxane (8 ml) and 1,4-dioxane (8 ml) containing the tert-butyl (2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-yl)carbamate (400 mg) obtained in (Example 3.15) <Step 4> was heated to reflux for 40 minutes. Thereafter, the precipitated solid was collected by filtration, and was then washed with 1,4-dioxane (15 ml). The obtained solid was dried to obtain the title compound (279 mg) in the form of a white solid.

Workup

  1. customobtained in (Example 3.15) <Step 4>
  2. temperaturewas heated
  3. temperatureto reflux for 40 minutes
  4. filtrationThereafter, the precipitated solid was collected by filtration
  5. washwas then washed with 1,4-dioxane (15 ml)
  6. customThe obtained solid was dried

Sources & evidence

ORD record
ord-fb9c287d09eb47e798457aaefe96e7f6
Source dataset
uspto-grants-2016_09
Patent number
US09440970B2

Reaction notes

Loading…