HCID 136358433, compound → HCID 136358434, compound

HRID 601409Notes

Reaction equation

HRID 601409 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]([CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:4](=[O:17])[C:3]=1[C:18]1[NH:23][C:22]2[CH:24]=[CH:25][C:26]([NH:28][S:29](=[O:45])(=[O:44])[N:30]([CH2:41][CH2:42][CH3:43])C(OCC3C=CC=CC=3)=O)=[CH:27][C:21]=2[S:20](=[O:47])(=[O:46])[N:19]=1>CO.[Pd]>[OH:1][C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]([CH2:12][CH2:13][CH:14]([CH3:15])[CH3:16])[C:4](=[O:17])[C:3]=1[C:18]1[NH:23][C:22]2[CH:24]=[CH:25][C:26]([NH:28][S:29]([NH:30][CH2:41][CH2:42][CH3:43])(=[O:45])=[O:44])=[CH:27][C:21]=2[S:20](=[O:47])(=[O:46])[N:19]=1

Participants

4

Reactant 1

HCID 136358433HCID 136358433, compound

Product 1

HCID 136358434HCID 136358434, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

A solution of the product of Example 438 in methanol is treated with 10% palladium on carbon and stirred at 25° C. for 5 hours under hydrogen atmosphere. The resulting solution is then filtered and the filtrate concentrated under reduced pressure to provide the title compound.

Workup

  1. filtrationThe resulting solution is then filtered
  2. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-de25479a50b14b55aa6cfa95d6874be3
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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