HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → 4-hydroxy-1-(3-methylbutyl)-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 4-(benzyloxy)-1-isopentyl-2(1H)-pyridinone | HCID 67063974 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-hydroxy-1-(3-methylbutyl)-1H-pyridin-2-one | HCID 66885665 | 100% |
Reaction Steps
The product of Example 457A (0.452 g, 1.67 mmol) in tetrahydrofuran (20 mL) was treated with ammonium formate (0.30 g, 5.01 mmol) and a catalytic amount of 20% palladium hydroxide on carbon at 60° C. for 2 hours. The reaction was filtered through diatomaceous earth and the filtrate concentrated under reduced pressure to provide the title compound (0.30 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902203B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-9205140998274540b5ea96a703301671 |
| Source note | uspto-grants-2011_03 |