Trifluoroacetic acid → HCID 136358521, compound

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	tert-butyl 3-[1-(cyclobutylamino)-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-ylcarbamate	HCID 136358522	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 136358521	HCID 136358521	91%

Reaction Conditions

Temperature	25 °C

Reaction Steps

A slurry of the product of Example 464A (1.5 g, 2.85 mmol) in dichloromethane (10 mL) at 0° C. was treated dropwise with 6 mL of trifluoroacetic acid, stirred at 25° C. for 2 hours and concentrated under reduced pressure. The residue was dissolved in ethyl acetate, washed with 10% aqueous sodium bicarbonate (3×50 mL), washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to provide the title compound (1.1 g, 91% yield).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07902203B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-3d069c64fe3d4374b5e99433fcc54895
Source note	uspto-grants-2011_03