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HRID601434

反应详情

EQUATION

反应方程式

HRID 601434 的结构方程式

REACTANTS

反应物

2
结构：CSC(SC)=C1C(=O)C=CN(CCC(C)C)C1=O
HCID10039590

未命名化合物

结构：CS(=O)(=O)Nc1ccc(N)c(S(N)(=O)=O)c1
HCID24950657

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)CCn1ccc(O)c(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)c1=O
HCID136036674

未命名化合物

收率 89%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度
25 °C

PROCEDURE

实验过程

A solution of the product of Example 457C (0.195 g, 0.68 mmol) in dioxane (10 mL) was reacted with the product of Example 425D (0.17 g, 0.64 mmol) at 115° C. for 1 hour. After cooling to about 25° C., the solid precipitate was collected by filtration and dried to provide the title compound (0.258 g, 89%). 1H NMR (300 MHz, DMSO-d6) δ 0.93 (d, J=6.25 Hz, 6 H) 1.58 (m, 3 H) 3.08 (s, 3 H) 3.99 (m, 2 H) 6.33 (d, J=6.62 Hz, 1 H) 7.57 (m, 2 H) 7.67 (d, J=8.82 Hz, 1 H) 8.07 (d, J=6.62 Hz, 1 H) 10.25 (s, 1 H) 13.84 (s, 1 H) 14.28 (s, 1 H). MS (ESI−) m/z 453 (M−H)−.

WORKUP

后处理

  1. filtrationthe solid precipitate was collected by filtration
  2. customdried