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温度

0 °C

To a solution of quetiapine (VI) (82.5 g, 215 mmol) in ethanol (660 ml) there was added fumaric acid (12.49 g, 108 mmol) and the mixture was heated under reflux for 2 hours in an inert atmosphere. A precipitate out of the solution formed shortly after starting the heating. After cooling the mixture to 0° C., it was filtered, washed with ethanol (250 ml, 0° C.) and dried at reduced pressure to give quetiapine hemifumarate (77.4 g, 81%) as a crystalline white solid.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2 hours in an inert atmosphere
3. customA precipitate out of the solution formed shortly
4. filtrationit was filtered
5. washwashed with ethanol (250 ml, 0° C.)
6. customdried at reduced pressure