Iodoethane → HCID 67273887, compound

Participants

Reaction Steps

KOH (1.476 g, 26.31 mmol) was added to a solution of 5-acetyl-4-methyl-3H-thiazol-2-one (4.134 g, 26.31 mmol) in DMSO (10 mL), and stirred at room temperature for 30 min. Iodoethane (2.525 mL, 31.57 mmol) was added and the resulting mixture stirred for 72 h. The reaction mixture was extracted into CH2Cl2 (5×30 mL) from H2O (30 mL) and the combined organic layers were dried over MgSO4, before passing through a short SiO2 gel column. Pooling of the desired fractions yielded the title compound (3.104 g, 64%).

Provenance & Evidence