Tetrahydrofuran → 4-Amino-4'-octylbiphenyl

Participants

Reaction Steps

4′-Nitro-4-n-octyl-biphenyl (1.2 g, 3.9 mmol) was added to a suspension of palladium on carbon (Pd/C, 1.0 g) in a mixed solvent of THF (60 mL) and ethanol (24 mL). The preparation was hydrogenized under constant hydrogen flow for 3 hours. The catalyst was filtered out, and the volatiles were removed in vacuo to give a pale yellow oil. Chromatography on silica gel gave 4-n-octyl-4′-amino-biphenyl as a colorless oil, which solidified upon standing (0.75 g, 67% yield).

Provenance & Evidence